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Epidemiological studies have shown a relationship between long-term use of proton pump inhibitors and bone metabolism. The FDA suggests those taking these drugs should consult with their doctors, and those using such drugs over-the-counter limit their use to no more than three 14-day periods a year. [The decision is] based on the Agency's review of several epidemiological studies that reported an increased risk of fractures of the hip, wrist and spine in patients using proton pump inhibitors." One of the most commonly prescribed drugs for heartburn and acid reflux are proton pump inhibitors (PPIs).
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The discovery and development of ciprofloxacin is that rare case of an actual groundbreaking new drug development, opening up an entire new class of antibiotics for further research, development, and marketing. Generic Name: Ciprofloxacin (oral) (SIP roe FLOX a sin) Brand Names: Cipro, Cipro XR, Proquin XR, Cipro I.